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The role of syntaxins in retinal function and health

Authors :
Lars Tebbe
Mashal Kakakhel
Muayyad R. Al-Ubaidi
Muna I. Naash
Source :
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Publication Year :
2024
Publisher :
Frontiers Media S.A., 2024.

Abstract

The soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptor (SNARE) superfamily plays a pivotal role in cellular trafficking by facilitating membrane fusion events. These SNARE proteins, including syntaxins, assemble into complexes that actively facilitate specific membrane fusion events. Syntaxins, as integral components of the SNARE complex, play a crucial role in initiating and regulating these fusion activities. While specific syntaxins have been extensively studied in various cellular processes, including neurotransmitter release, autophagy and endoplasmic reticulum (ER)-to-Golgi protein transport, their roles in the retina remain less explored. This review aims to enhance our understanding of syntaxins’ functions in the retina by shedding light on how syntaxins mediate membrane fusion events unique to the retina. Additionally, we seek to establish a connection between syntaxin mutations and retinal diseases. By exploring the intricate interplay of syntaxins in retinal function and health, we aim to contribute to the broader comprehension of cellular trafficking in the context of retinal physiology and pathology.

Details

Language :
English
ISSN :
16625102
Volume :
18
Database :
Directory of Open Access Journals
Journal :
Frontiers in Cellular Neuroscience
Publication Type :
Academic Journal
Accession number :
edsdoj.59b42f60dad6486db10701d04a42dd02
Document Type :
article
Full Text :
https://doi.org/10.3389/fncel.2024.1380064