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Targeted Repair of Spinal Cord Injury Based on miRNA‐124‐3p–Loaded Mesoporous Silica Camouflaged by Stem Cell Membrane Modified with Rabies Virus Glycoprotein

Authors :
Xiangchuang Fan
Lusen Shi
Zimeng Yang
Yiwei Li
Chi Zhang
Baoshuai Bai
Lu Chen
Elzat Elham‐Yilizati Yilihamu
Zhangyang Qi
Wenxiang Li
Peng Xiao
Mingshan Liu
Jichuan Qiu
Fan Yang
Ning Ran
Yifan Shang
Jiaxing Liu
Tehan Zhang
Xiaohong Kong
Hong Liu
Hengxing Zhou
Shiqing Feng
Source :
Advanced Science, Vol 11, Iss 21, Pp n/a-n/a (2024)
Publication Year :
2024
Publisher :
Wiley, 2024.

Abstract

Abstract Spinal cord injury (SCI) has no effective treatment modalities. It faces a significant global therapeutical challenge, given its features of poor axon regeneration, progressive local inflammation, and inefficient systemic drug delivery due to the blood–spinal cord barrier (BSCB). To address these challenges, a new nano complex that achieves targeted drug delivery to the damaged spinal cord is proposed, which contains a mesoporous silica nanoparticle core loaded with microRNA and a cloaking layer of human umbilical cord mesenchymal stem cell membrane modified with rabies virus glycoprotein (RVG). The nano complex more readily crosses the damaged BSCB with its exosome‐resembling properties, including appropriate size and a low‐immunogenic cell membrane disguise and accumulates in the injury center because of RVG, where it releases abundant microRNAs to elicit axon sprouting and rehabilitate the inflammatory microenvironment. Culturing with nano complexes promotes axonal growth in neurons and M2 polarization in microglia. Furthermore, it showed that SCI mice treated with this nano complex by tail vein injection display significant improvement in axon regrowth, microenvironment regulation, and functional restoration. The efficacy and biocompatibility of the targeted delivery of microRNA by nano complexes demonstrate their immense potential as a noninvasive treatment for SCI.

Details

Language :
English
ISSN :
21983844
Volume :
11
Issue :
21
Database :
Directory of Open Access Journals
Journal :
Advanced Science
Publication Type :
Academic Journal
Accession number :
edsdoj.59a6757c050e4ba981c588ea0711996a
Document Type :
article
Full Text :
https://doi.org/10.1002/advs.202309305