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DBP rs7041 and DHCR7 rs3829251 are Linked to CD4+ Recovery in HIV Patients on Antiretroviral Therapy

Authors :
Salvador Resino
María Ángeles Jiménez-Sousa
Julià Blanco
Yolanda M. Pacheco
Jorge del Romero
Joaquim Peraire
Ana Virseda-Berdices
María José Muñoz-Gómez
Carlos Galera-Peñaranda
Lucio Jesus García-Fraile
José M. Benito
Norma Rallón
Source :
Frontiers in Pharmacology, Vol 12 (2022)
Publication Year :
2022
Publisher :
Frontiers Media S.A., 2022.

Abstract

Background: The lack of the recovery of CD4+ T-cells (CD4+ recovery) among immunodeficiency virus (HIV)-infected patients on antiretroviral therapy (ART) is not well known. We aimed to analyze the association between single nucleotide polymorphisms (SNPs) underlying vitamin D metabolism and the CD4+ recovery in naïve HIV-infected patients who started ART with low baseline CD4+.Methods: We conducted a retrospective study in 411 naïve individuals with plasma HIV load >200 copies/mL and CD4+

Details

Language :
English
ISSN :
16639812
Volume :
12
Database :
Directory of Open Access Journals
Journal :
Frontiers in Pharmacology
Publication Type :
Academic Journal
Accession number :
edsdoj.59a3d604aaf24ddba2ceeacd09f08f52
Document Type :
article
Full Text :
https://doi.org/10.3389/fphar.2021.773848