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Characterization of the Myocardial Inflammatory Response in Acute Stress-Induced (Takotsubo) Cardiomyopathy
- Source :
- JACC: Basic to Translational Science, Vol 3, Iss 6, Pp 766-778 (2018)
- Publication Year :
- 2018
- Publisher :
- Elsevier, 2018.
-
Abstract
- Summary: Takotsubo cardiomyopathy is an acute stress-induced heart failure syndrome for which the exact pathogenic mechanisms are unclear, and consequently, no specific treatment exists. In an experimental model of stress-induced takotsubo-like cardiomyopathy, the authors describe the temporal course of a chronic inflammatory response post-induction, with an initial early influx of neutrophils into myocardial tissue followed by macrophages that are typical of a proinflammatory M1 phenotype, and a nonsignificant increase in systemic inflammatory cytokines. Post-mortem myocardium from the more complex clinical takotsubo patients share features of the study’s experimental model. These findings suggest modulators of inflammation could be a potential therapeutic option. Key Words: histopathology, inflammation, macrophage, pathophysiology, takotsubo cardiomyopathy
- Subjects :
- Diseases of the circulatory (Cardiovascular) system
RC666-701
Subjects
Details
- Language :
- English
- ISSN :
- 2452302X
- Volume :
- 3
- Issue :
- 6
- Database :
- Directory of Open Access Journals
- Journal :
- JACC: Basic to Translational Science
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.599c0eb19d34559a0e49a6102edd242
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.jacbts.2018.08.006