Back to Search Start Over

Bile acid nuclear receptor FXR and digestive system diseases

Authors :
Lili Ding
Li Yang
Zhengtao Wang
Wendong Huang
Source :
Acta Pharmaceutica Sinica B, Vol 5, Iss 2, Pp 135-144 (2015)
Publication Year :
2015
Publisher :
Elsevier, 2015.

Abstract

Bile acids (BAs) are not only digestive surfactants but also important cell signaling molecules, which stimulate several signaling pathways to regulate some important biological processes. The bile-acid-activated nuclear receptor, farnesoid X receptor (FXR), plays a pivotal role in regulating bile acid, lipid and glucose homeostasis as well as in regulating the inflammatory responses, barrier function and prevention of bacterial translocation in the intestinal tract. As expected, FXR is involved in the pathophysiology of a wide range of diseases of gastrointestinal tract, including inflammatory bowel disease, colorectal cancer and type 2 diabetes. In this review, we discuss current knowledge of the roles of FXR in physiology of the digestive system and the related diseases. Better understanding of the roles of FXR in digestive system will accelerate the development of FXR ligands/modulators for the treatment of digestive system diseases.

Details

Language :
English
ISSN :
22113835 and 22113843
Volume :
5
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Acta Pharmaceutica Sinica B
Publication Type :
Academic Journal
Accession number :
edsdoj.5987021cb5df4a77bf819967f71fb6bf
Document Type :
article
Full Text :
https://doi.org/10.1016/j.apsb.2015.01.004