Citrullus colocynthis fruit resin and Cyperus rotundus tuber resin: Assessing their analgesic effects with hot plate and writhing tests

The hot plate test and writhing test were both employed to investigate the analgesic effects of Citrullus colocynthis fruit resin and Cyperus rotundus tuber resin at varying concentrations and time intervals. The hot-plate test results revealed that Citrullus colocynthis fruit resin demonstrated significant dose-dependent and time-dependent analgesic effects. In contrast, Cyperus rotundus Tuber resin did not exhibit substantial analgesic effects in the hot-plate test. In the writhing test, Citrullus colocynthis fruit resin exhibited clear dose-dependent analgesic effects at higher concentrations. Cyperus rotundus Tuber resin demonstrated significant analgesic effects in reducing writhing responses, although its efficacy was not as potent as the positive control indomethacin. These results offer insights into the potential use of these natural resins for pain management while also highlighting the importance of understanding the underlying mechanisms of their analgesic effects for further clinical applications.