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Ameliorative effect of Odontonema cuspidatum extract against testicular damage induced by sodium nitrite in rats
- Source :
- Open Veterinary Journal, Vol 14, Iss (1) (Zagazig Veterinary Conference), Pp 304-315 (2024)
- Publication Year :
- 2024
- Publisher :
- Tripoli University, 2024.
-
Abstract
- Background: Sodium nitrite (NaNO2) is a chemical substance used to enhance taste, add color, and keep food products fit for consumption for a longer time. NaNO2 gives rise to a negative adverse effect on male reproductive function. Odontonema cuspidatum (OC) is a natural plant that possesses antioxidant capacity. Aim: Our research evaluates the potential beneficial effect of Odontonema cuspidatum extract on the harmful effects caused by NaNO2 on the testicular tissue and sperm characteristics of male rats. Methods: Four groups with a total of forty rats: the control, the NaNO2-received group, the OC-administered group, and the fourth group received both NaNO2 and OC. All groups were administered daily for two months. Sperm characteristics, testicular antioxidant status and histopathological changes were evaluated. Results: Coadministration of NaNO2 and OC, in comparison with NaNO2 alone, contributed to a notable enhancement in acrosomal integrity, decreasing sperm abnormalities and restoring serum testosterone levels. Moreover, such coadministration reduced the oxidative stress marker, MDA, and increased SOD in testicular tissue, lowering TNF-α gene expression, and increasing the expression of P450scc and StAR genes. Additionally, the NaNO2 and OC combination decreased the testicular histopathological changes and the Caspase-3 and PCNA immunoexpression in seminiferous tubules compared with the NaNO2 group. Conclusion: The extract of Odontonema cuspidatum exhibited the ability to decrease oxidative stress and ameliorate the detrimental effects caused by NaNO2. [Open Vet J 2024; 14(1.000): 304-315]
- Subjects :
- nano2
odontonema cuspidatum
food additives
testicular damage
Zoology
QL1-991
Subjects
Details
- Language :
- English
- ISSN :
- 22264485 and 22186050
- Volume :
- 14
- Issue :
- (1) (Zagazig Veterinary Conference)
- Database :
- Directory of Open Access Journals
- Journal :
- Open Veterinary Journal
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.592919b6e4db4e91ab599678e48a6f10
- Document Type :
- article
- Full Text :
- https://doi.org/10.5455/OVJ.2024.v14.i1.27