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Mechanism of the natural product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1α inhibition

Authors :
Nak-Kyun Soung
Hye-Min Kim
Yukihiro Asami
Dong Hyun Kim
Yangrae Cho
Ravi Naik
Yerin Jang
Kusic Jang
Ho Jin Han
Srinivas Rao Ganipisetti
Hyunjoo Cha-Molstad
Joonsung Hwang
Kyung Ho Lee
Sung-Kyun Ko
Jae-Hyuk Jang
In-Ja Ryoo
Yong Tae Kwon
Kyung Sang Lee
Hiroyuki Osada
Kyeong Lee
Bo Yeon Kim
Jong Seog Ahn
Source :
Experimental and Molecular Medicine, Vol 51, Iss 2, Pp 1-14 (2019)
Publication Year :
2019
Publisher :
Nature Publishing Group, 2019.

Abstract

Cancer: How a plant metabolite analog suppresses tumor growth A synthetic analog of a chemical found in fruit suppresses tumor growth by targeting an RNA-binding protein (hnRNPA2B1) and preventing the production of a pro-cancer regulatory factor. Nak-Kyun Soung from the Korea Research Institute of Bioscience and Biotechnology, Cheongju, South Korea, and coworkers built on their previous discovery that a compound derived from a medicinal plant metabolite can suppress the activity of hypoxia-inducible factor-1α (HIF-1α). This protein, which is involved in many aspects of cancer biology, is activated in the low-oxygen microenvironments found inside tumors. The researchers show that the compound binds to a protein that helps with the conversion of HIF-1α–encoding RNA transcripts into HIF-1α proteins. Liver cancer cells treated with the compound grew slowly and produced less HIF-1α under both normal and low-oxygen culture conditions, highlighting the potential of this anti-cancer strategy.

Subjects

Subjects :
Medicine
Biochemistry
QD415-436

Details

Language :
English
ISSN :
12263613, 20926413, and 13899708
Volume :
51
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Experimental and Molecular Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.590b138997084a14a74110e5433070ff
Document Type :
article
Full Text :
https://doi.org/10.1038/s12276-018-0200-4