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Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

Authors :
Tuomas O. Kilpeläinen
Jayne F. Martin Carli
Alicja A. Skowronski
Qi Sun
Jennifer Kriebel
Mary F Feitosa
Åsa K. Hedman
Alexander W. Drong
James E. Hayes
Jinghua Zhao
Tune H. Pers
Ursula Schick
Niels Grarup
Zoltán Kutalik
Stella Trompet
Massimo Mangino
Kati Kristiansson
Marian Beekman
Leo-Pekka Lyytikäinen
Joel Eriksson
Peter Henneman
Jari Lahti
Toshiko Tanaka
Jian’an Luan
Fabiola Del Greco M
Dorota Pasko
Frida Renström
Sara M. Willems
Anubha Mahajan
Lynda M. Rose
Xiuqing Guo
Yongmei Liu
Marcus E. Kleber
Louis Pérusse
Tom Gaunt
Tarunveer S. Ahluwalia
Yun Ju Sung
Yolande F. Ramos
Najaf Amin
Antoinette Amuzu
Inês Barroso
Claire Bellis
John Blangero
Brendan M. Buckley
Stefan Böhringer
Yii-Der I Chen
Anton J. N. de Craen
David R. Crosslin
Caroline E. Dale
Zari Dastani
Felix R. Day
Joris Deelen
Graciela E. Delgado
Ayse Demirkan
Francis M. Finucane
Ian Ford
Melissa E. Garcia
Christian Gieger
Stefan Gustafsson
Göran Hallmans
Susan E. Hankinson
Aki S Havulinna
Christian Herder
Dena Hernandez
Andrew A. Hicks
David J. Hunter
Thomas Illig
Erik Ingelsson
Andreea Ioan-Facsinay
John-Olov Jansson
Nancy S. Jenny
Marit E. Jørgensen
Torben Jørgensen
Magnus Karlsson
Wolfgang Koenig
Peter Kraft
Joanneke Kwekkeboom
Tiina Laatikainen
Karl-Heinz Ladwig
Charles A. LeDuc
Gordon Lowe
Yingchang Lu
Pedro Marques-Vidal
Christa Meisinger
Cristina Menni
Andrew P. Morris
Richard H. Myers
Satu Männistö
Mike A. Nalls
Lavinia Paternoster
Annette Peters
Aruna D. Pradhan
Tuomo Rankinen
Laura J. Rasmussen-Torvik
Wolfgang Rathmann
Treva K. Rice
J Brent Richards
Paul M. Ridker
Naveed Sattar
David B. Savage
Stefan Söderberg
Nicholas J. Timpson
Liesbeth Vandenput
Diana van Heemst
Hae-Won Uh
Marie-Claude Vohl
Mark Walker
Heinz-Erich Wichmann
Elisabeth Widén
Andrew R. Wood
Jie Yao
Tanja Zeller
Yiying Zhang
Ingrid Meulenbelt
Margreet Kloppenburg
Arne Astrup
Thorkild I. A. Sørensen
Mark A. Sarzynski
D. C. Rao
Pekka Jousilahti
Erkki Vartiainen
Albert Hofman
Fernando Rivadeneira
André G. Uitterlinden
Eero Kajantie
Clive Osmond
Aarno Palotie
Johan G. Eriksson
Markku Heliövaara
Paul B. Knekt
Seppo Koskinen
Antti Jula
Markus Perola
Risto K. Huupponen
Jorma S. Viikari
Mika Kähönen
Terho Lehtimäki
Olli T. Raitakari
Dan Mellström
Mattias Lorentzon
Juan P. Casas
Stefanie Bandinelli
Winfried März
Aaron Isaacs
Ko W. van Dijk
Cornelia M. van Duijn
Tamara B. Harris
Claude Bouchard
Matthew A. Allison
Daniel I. Chasman
Claes Ohlsson
Lars Lind
Robert A. Scott
Claudia Langenberg
Nicholas J. Wareham
Luigi Ferrucci
Timothy M. Frayling
Peter P. Pramstaller
Ingrid B. Borecki
Dawn M. Waterworth
Sven Bergmann
Gérard Waeber
Peter Vollenweider
Henrik Vestergaard
Torben Hansen
Oluf Pedersen
Frank B. Hu
P Eline Slagboom
Harald Grallert
Tim D. Spector
J.W. Jukema
Robert J. Klein
Erik E Schadt
Paul W. Franks
Cecilia M. Lindgren
Rudolph L. Leibel
Ruth J. F. Loos
Source :
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Publication Year :
2016
Publisher :
Nature Portfolio, 2016.

Abstract

This meta-analysis of genome-wide association studies identifies four genetic loci associated with circulating leptin levels independent of adiposity. Examination in mouse adipose tissue explants provides functional support for the leptin-associated loci.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
7
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.58d296ffd8e4ac5ad80fa53bbfc1121
Document Type :
article
Full Text :
https://doi.org/10.1038/ncomms10494