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LYN kinase programs stromal fibroblasts to facilitate leukemic survival via regulation of c-JUN and THBS1
- Source :
- Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
- Publication Year :
- 2023
- Publisher :
- Nature Portfolio, 2023.
-
Abstract
- The survival of chronic lymphocytic leukemia cells strongly depends on the presence of a supportive microenvironment. Here, the authors show that LYN kinase is essential for the reprogramming of stromal cells towards a leukemia-supportive phenotype that facilitates disease progression.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 14
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.5884daf4f87c4769b8607b371a457bb5
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-023-36824-2