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A genetically encoded anti-CRISPR protein constrains gene drive spread and prevents population suppression

Authors :
Chrysanthi Taxiarchi
Andrea Beaghton
Nayomi Illansinhage Don
Kyros Kyrou
Matthew Gribble
Dammy Shittu
Scott P. Collins
Chase L. Beisel
Roberto Galizi
Andrea Crisanti
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Technologies that can halt the spread of gene drives would be highly useful in controlling or reverting their effect. Here the authors use the anti-CRISPR protein AcrIIA4 to inactivate drives in A. gambiae.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.5874a5ae9a2467ba0f3206162213461
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-24214-5