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Cortical Pathology in RRMS: Taking a Cue from Four Sisters
- Source :
- Multiple Sclerosis International, Vol 2012 (2012)
- Publication Year :
- 2012
- Publisher :
- Wiley, 2012.
-
Abstract
- Background. Although grey matter pathology is a relevant aspect of multiple sclerosis (MS) both with physical and cognitive rebounds, its pathogenesis is still under investigation. To what extent the familial and sporadic cases of MS differ in cortical pathology has not been elucidated yet. Here we present a multiple case report of four sisters affected by MS, all of them having a very high burden of cortical pathology. Methods. The clinical and grey matter MRI parameters of the patients were compared with those of twenty-five-aged matched healthy women and 25 women affected by sporadic MS (matched for age, disease duration, EDSS, and white matter lesion load). Results. Despite their short disease duration (
- Subjects :
- Neurology. Diseases of the nervous system
RC346-429
Subjects
Details
- Language :
- English
- ISSN :
- 20902654 and 20902662
- Volume :
- 2012
- Database :
- Directory of Open Access Journals
- Journal :
- Multiple Sclerosis International
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.58321e484a254af98e8b943c67274bd5
- Document Type :
- article
- Full Text :
- https://doi.org/10.1155/2012/760254