Back to Search Start Over

Non-coding RNAs and glioblastoma: Insight into their roles in metastasis

Authors :
Seyed Mojtaba Mousavi
Maryam Derakhshan
Fatereh Baharloii
Fatemeh Dashti
Seyed Mohammad Ali Mirazimi
Maryam Mahjoubin-Tehran
Saereh Hosseindoost
Pouya Goleij
Neda Rahimian
Michael R. Hamblin
Hamed Mirzaei
Source :
Molecular Therapy: Oncolytics, Vol 24, Iss , Pp 262-287 (2022)
Publication Year :
2022
Publisher :
Elsevier, 2022.

Abstract

Glioma, also known as glioblastoma multiforme (GBM), is the most prevalent and most lethal primary brain tumor in adults. Gliomas are highly invasive tumors with the highest death rate among all primary brain malignancies. Metastasis occurs as the tumor cells spread from the site of origin to another site in the brain. Metastasis is a multifactorial process, which depends on alterations in metabolism, genetic mutations, and the cancer microenvironment. During recent years, the scientific study of non-coding RNAs (ncRNAs) has led to new insight into the molecular mechanisms involved in glioma. Many studies have reported that ncRNAs play major roles in many biological procedures connected with the development and progression of glioma. Long ncRNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs) are all types of ncRNAs, which are commonly dysregulated in GBM. Dysregulation of ncRNAs can facilitate the invasion and metastasis of glioma. The present review highlights some ncRNAs that have been associated with metastasis in GBM. miRNAs, circRNAs, and lncRNAs are discussed in detail with respect to their relevant signaling pathways involved in metastasis.

Details

Language :
English
ISSN :
23727705
Volume :
24
Issue :
262-287
Database :
Directory of Open Access Journals
Journal :
Molecular Therapy: Oncolytics
Publication Type :
Academic Journal
Accession number :
edsdoj.582b702e3eae42fbab9f5887b3e6b26e
Document Type :
article
Full Text :
https://doi.org/10.1016/j.omto.2021.12.015