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COVID-19 In-Hospital Mortality in People with Diabetes Is Driven by Comorbidities and Age—Propensity Score-Matched Analysis of Austrian National Public Health Institute Data

Authors :
Faisal Aziz
Felix Aberer
Alexander Bräuer
Christian Ciardi
Martin Clodi
Peter Fasching
Mario Karolyi
Alexandra Kautzky-Willer
Carmen Klammer
Oliver Malle
Erich Pawelka
Thomas Pieber
Slobodan Peric
Claudia Ress
Michael Schranz
Caren Sourij
Lars Stechemesser
Harald Stingl
Hannah Stöcher
Thomas Stulnig
Norbert Tripolt
Michael Wagner
Peter Wolf
Andreas Zitterl
Alexander Christian Reisinger
Jolanta Siller-Matula
Michael Hummer
Othmar Moser
Dirk von-Lewinski
Philipp Eller
Susanne Kaser
Harald Sourij
Source :
Viruses, Vol 13, Iss 12, p 2401 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Background: It is a matter of debate whether diabetes alone or its associated comorbidities are responsible for severe COVID-19 outcomes. This study assessed the impact of diabetes on intensive care unit (ICU) admission and in-hospital mortality in hospitalized COVID-19 patients. Methods: A retrospective analysis was performed on a countrywide cohort of 40,632 COVID-19 patients hospitalized between March 2020 and March 2021. Data were provided by the Austrian data platform. The association of diabetes with outcomes was assessed using unmatched and propensity-score matched (PSM) logistic regression. Results: 12.2% of patients had diabetes, 14.5% were admitted to the ICU, and 16.2% died in the hospital. Unmatched logistic regression analysis showed a significant association of diabetes (odds ratio [OR]: 1.24, 95% confidence interval [CI]: 1.15–1.34, p < 0.001) with in-hospital mortality, whereas PSM analysis showed no significant association of diabetes with in-hospital mortality (OR: 1.08, 95%CI: 0.97–1.19, p = 0.146). Diabetes was associated with higher odds of ICU admissions in both unmatched (OR: 1.36, 95%CI: 1.25–1.47, p < 0.001) and PSM analysis (OR: 1.15, 95%CI: 1.04–1.28, p = 0.009). Conclusions: People with diabetes were more likely to be admitted to ICU compared to those without diabetes. However, advanced age and comorbidities rather than diabetes itself were associated with increased in-hospital mortality in COVID-19 patients.

Details

Language :
English
ISSN :
13122401 and 19994915
Volume :
13
Issue :
12
Database :
Directory of Open Access Journals
Journal :
Viruses
Publication Type :
Academic Journal
Accession number :
edsdoj.5826eb68d4b84e80863300626cd03b30
Document Type :
article
Full Text :
https://doi.org/10.3390/v13122401