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Divergent Synthesis of Four Monomeric Ellagitannins toward the Total Synthesis of an Oligomeric Ellagitannin, Nobotanin K

Authors :
Hajime Hashimoto
Shinnosuke Wakamori
Kazutada Ikeuchi
Hidetoshi Yamada
Source :
Organics, Vol 3, Iss 3, Pp 293-303 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Oligomeric ellagitannins are challenging synthetic targets due to the need for an abundant supply of their composed monomeric ellagitannins and a synthetic methodology to connect them. This work focused on the divergent synthesis of the four monomeric ellagitannins from a common intermediate as a step toward the total synthesis of nobotanin K, a class of compounds that includes oligomeric ellagitannins and were isolated in plants belonging to the Melastomataceae family. Implementing our method, the four natural products could be easily supplied, suggesting that through this novel route, the total synthesis of nobotanin K could be achieved smoothly.

Details

Language :
English
ISSN :
2673401X
Volume :
3
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Organics
Publication Type :
Academic Journal
Accession number :
edsdoj.57a56a57727b43498d52aee319bb7afd
Document Type :
article
Full Text :
https://doi.org/10.3390/org3030022