Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates

Rhee, Pokrovskaya et al. utilize 3D electron microscopy of mouse jugular vein puncture wounds to reveal thrombi structured around localized, nucleated platelet aggregates that produced a vaulted thrombus capped by extravascular platelet adherence. As a result, the authors propose a “Cap and Build” paradigm of primary hemostasis.