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The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study

The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study

Authors :
Christian Jung
Hans Flaatten
Jesper Fjølner
Raphael Romano Bruno
Bernhard Wernly
Antonio Artigas
Bernardo Bollen Pinto
Joerg C. Schefold
Georg Wolff
Malte Kelm
Michael Beil
Sigal Sviri
Peter Vernon van Heerden
Wojciech Szczeklik
Miroslaw Czuczwar
Muhammed Elhadi
Michael Joannidis
Sandra Oeyen
Tilemachos Zafeiridis
Brian Marsh
Finn H. Andersen
Rui Moreno
Maurizio Cecconi
Susannah Leaver
Ariane Boumendil
Dylan W. De Lange
Bertrand Guidet
COVIP study group
Source :
Critical Care, Vol 25, Iss 1, Pp 1-9 (2021)
Publication Year :
2021
Publisher :
BMC, 2021.

Abstract

Abstract Background The COVID-19 pandemic has led highly developed healthcare systems to the brink of collapse due to the large numbers of patients being admitted into hospitals. One of the potential prognostic indicators in patients with COVID-19 is frailty. The degree of frailty could be used to assist both the triage into intensive care, and decisions regarding treatment limitations. Our study sought to determine the interaction of frailty and age in elderly COVID-19 ICU patients. Methods A prospective multicentre study of COVID-19 patients ≥ 70 years admitted to intensive care in 138 ICUs from 28 countries was conducted. The primary endpoint was 30-day mortality. Frailty was assessed using the clinical frailty scale. Additionally, comorbidities, management strategies and treatment limitations were recorded. Results The study included 1346 patients (28% female) with a median age of 75 years (IQR 72–78, range 70–96), 16.3% were older than 80 years, and 21% of the patients were frail. The overall survival at 30 days was 59% (95% CI 56–62), with 66% (63–69) in fit, 53% (47–61) in vulnerable and 41% (35–47) in frail patients (p

Details

Language :
English
ISSN :
13648535
Volume :
25
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Critical Care
Publication Type :
Academic Journal
Accession number :
edsdoj.56eb45c9fe4788a0d6c8efb8fd5675
Document Type :
article
Full Text :
https://doi.org/10.1186/s13054-021-03551-3