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Mimosa pudica leaf aqueous extract attenuates experimental ulcerative colitis in rats via suppression of MPO and IL-1β signaling pathways and improvement of the oxidative status
- Source :
- Phytomedicine Plus, Vol 4, Iss 2, Pp 100559- (2024)
- Publication Year :
- 2024
- Publisher :
- Elsevier, 2024.
-
Abstract
- Background: Colitis for so many years had been considered a disease exclusive only to developed countries; surprisingly, its incidence is now increasing worldwide. This study investigated Mimosa pudica leaf water extract anti-colitis potential on acetic acid-induced colitis in rats. Methods: Following 24 h fasting, 36 rats (both sexes) intrarectally received acetic acid (4%, 1 mL) to induce colitis. Afterward, they were separated into groups and treated twice a day (for 9 days) with distilled water; Mimosa pudica (25, 50, or 100 mg/kg); and Prednisolone (5 mg/kg). Body weight and quantity of feces were recorded. On day 9, animals were sacrificed, colon ulcerations number and weight/length ratio; GSH and MDA levels; MPO activity, and IL-1β were determined. Results: Colitis caused a significant drop in animals’ body weight - 30% decrease in colitis control against + 27% increase in the neutral control rats. Mimosa pudica at 25 mg/kg on day 9 brought a + 7% increase. Colitis led to an increase in the weight of feces in colitis rats with 14.28 ± 0.98 g (day 8). On this same day, the extract reduced feces weight (4.42 ± 0.31 g at 100 mg/kg), the number of colon ulcerations, and the mean colon weight/length ratio (P < 0.001). Colitis conditions increased MDA and decreased GSH. Mimosa pudica reversed these biomarkers. Colitis caused a marked increase in MPO activity and IL-1β concentration in colitis rats. This was reversed by the extract. Conclusions: Overall, our results proved the beneficial effects of Mimosa pudica leaf extract in protecting animals against colitis.
Details
- Language :
- English
- ISSN :
- 26670313
- Volume :
- 4
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Phytomedicine Plus
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.56db882c6bd3457b9d256ae51c637d7a
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.phyplu.2024.100559