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Aspartame, as an artificial sweetener, does not affect renal function and antioxidative states in mice

Authors :
Kenta Torigoe
Miki Torigoe
Satoru Oka
Yoko Obata
Hiroshi Mukae
Tomoya Nishino
Source :
BMC Research Notes, Vol 17, Iss 1, Pp 1-7 (2024)
Publication Year :
2024
Publisher :
BMC, 2024.

Abstract

Abstract Background and objective Aspartame (l-aspartyl l-phenylalanine methyl ester) is an artificial sweetener widely used as a sugar substitute. There are concerns regarding the effects of high aspartame doses on the kidney owing to oxidative stress; however, whether the maximum allowed dose of aspartame in humans affects the kidneys remains unknown. Therefore, in this study, we investigated whether the maximum allowed dose of aspartame in humans affects the kidneys. Methods In this study, animals were fed a folate-deficient diet to mimic human aspartame metabolism. Eight-week-old ICR mice were divided into control (CTL), 40 mg/kg/day of aspartame-administered (ASP), folate-deficient diet (FD), and 40 mg/kg/day of aspartame-administered with a folate-deficient diet (FD + ASP) groups. Aspartame was administered orally for eight weeks. Thereafter, we evaluated aspartame’s effect on kidneys via histological analysis. Results There were no differences in serum creatinine and blood urea nitrogen levels between the CTL and ASP groups or between the FD and FD + ASP groups. There was no histological change in the kidneys in any group. The expression of superoxide dismutase and 4-hydroxy-2-nonenal in the kidney did not differ between the CTL and ASP groups or the FD and FD + ASP groups. Conclusion Our findings indicate that the allowed doses of aspartame in humans may not affect kidney function or oxidative states.

Details

Language :
English
ISSN :
17560500
Volume :
17
Issue :
1
Database :
Directory of Open Access Journals
Journal :
BMC Research Notes
Publication Type :
Academic Journal
Accession number :
edsdoj.56c44401bf54a35b28bb65caa4773fe
Document Type :
article
Full Text :
https://doi.org/10.1186/s13104-024-06816-6