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Multiple Venous and Pulmonary Artery Thrombosis as the Presenting Features of Spontaneously Reversible Nephrotic Syndrome after Exposure to SARS-CoV-2 Virus (Pfizer/BioNTech BNT162b2) Vaccination

Authors :
Theerachai Thammathiwat
Athiphat Banjongjit
Piyatida Chumnumsiriwath
Laor Chompuk
Apichaya Sripariwuth
Sutatip Pongcharoen
Talerngsak Kanjanabuch
Source :
Vaccines, Vol 10, Iss 11, p 1888 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

We report an unusual case of nephrotic syndrome and multiple venous thromboembolism (VTE) four days after BNT162b2 injection. The patient presented with a three-day history of foamy urine and one-day history of right leg swelling. The investigation showed 9.5 g of 24 hr urine protein, hypoalbuminemia (2.6 gm/dL), and hypercholesterolemia (320 mg/dL). The duplex ultrasonography revealed VTE of the right lower extremity veins (common femoral vein, saphenous vein, and popliteal vein). Computed tomography (CT) showed thrombosis of the infrarenal inferior vena cava (IVC) extending to both iliac veins and acute pulmonary embolism. Kidney biopsy was performed. The diagnosis of minimal change disease was made. The patient received anticoagulation without steroid or immunosuppressive medications. The nephrosis was spontaneously resolved in 20 days; thus, it strongly suggested the diagnosis of vaccine-induced minimal change nephropathy. Reports of kidney adverse events and clinical characteristics are further needed in the circumstances of worldwide SARS-CoV-2 vaccine usage.

Details

Language :
English
ISSN :
2076393X
Volume :
10
Issue :
11
Database :
Directory of Open Access Journals
Journal :
Vaccines
Publication Type :
Academic Journal
Accession number :
edsdoj.5683311d4a421f9b8198a6539049f7
Document Type :
article
Full Text :
https://doi.org/10.3390/vaccines10111888