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c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression
- Source :
- Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
- Publication Year :
- 2019
- Publisher :
- Nature Portfolio, 2019.
-
Abstract
- HGF/c-MET upregulation is frequent in bladder cancer. Here, the authors show that HGF induces EMT and invasion by stabilising TGFβ receptor through inhibition of the SMURF2 ligase, and the combined blockade of MAPK and TGFβ pathways suppresses HGF-mediated bladder cancer progression.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 10
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.563b6db7c52440f8cb6c74048d684b4
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-019-12241-2