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Patient-reported outcomes and neurotoxicity markers in patients treated with bispecific LV20.19 CAR T cell therapy

Authors :
Jennifer M. Knight
Aniko Szabo
Igli Arapi
Ruizhe Wu
Amanda Emmrich
Edward Hackett
Garrett Sauber
Sharon Yim
Bryon Johnson
Parameswaran Hari
Dina Schneider
Boro Dropulic
Rachel N. Cusatis
Steve W. Cole
Cecilia J. Hillard
Nirav N. Shah
Source :
Communications Medicine, Vol 2, Iss 1, Pp 1-10 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Knight et al. assess short-term patient-reported outcomes (PROs) and markers of neurotoxicity in patients with leukaemia or lymphoma treated with LV20.19 CAR T cells. In this small trial cohort, the authors report improvements in mood following CAR T infusion and identify kynurenine pathway molecules as potential markers of mood and neurotoxicity.

Subjects

Subjects :
Medicine

Details

Language :
English
ISSN :
2730664X
Volume :
2
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.56255e90ea724f659420f005396f9009
Document Type :
article
Full Text :
https://doi.org/10.1038/s43856-022-00116-5