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Tamoxifen prolongs survival and alleviates symptoms in mice with fatal X-linked myotubular myopathy
- Source :
- Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
- Publication Year :
- 2018
- Publisher :
- Nature Portfolio, 2018.
-
Abstract
- X-linked myotubular myopathy (XLMTM) is a severe muscle disease with no effective treatment. Here, the authors show that tamoxifen, a drug used to treat breast cancer, rescues the pathology in a mouse model of the disease, at least in part by normalizing expression of the disease modifier proteins DNM2 and BIN1
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 9
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.55e31f0f62ce4d928b4e2b13a82b1d60
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-018-07058-4