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Effects of Unilateral High Frequency Stimulation of the Subthalamic Nucleus on Risk-avoidant Behavior in a Partial 6-hydroxydopamine Model of Parkinson's Disease
- Source :
- Journal of Integrative Neuroscience, Vol 23, Iss 4, p 84 (2024)
- Publication Year :
- 2024
- Publisher :
- IMR Press, 2024.
-
Abstract
- Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-established treatment for the motor symptoms of Parkinson’s disease (PD). While PD is primarily characterized by motor symptoms such as tremor, rigidity, and bradykinesia, it also involves a range of non-motor symptoms, and anxiety is one of the most common. The relationship between PD and anxiety is complex and can be a result of both pathological neural changes and the psychological and emotional impacts of living with a chronic progressive condition. Managing anxiety in PD is critical for improving the patients’ quality of life. However, patients undergoing STN DBS can occasionally experience increased anxiety. Methods: This study investigates changes in risk-avoidant behavior following STN DBS in a pre-motor animal model of PD under chronic and acute unilateral high frequency stimulation. Results: No significant changes in risk-avoidant behaviors were observed in rats who underwent STN DBS compared with sham stimulation controls. Chronic stimulation prevented sensitization in the elevated zero maze. Conclusions: These results suggest that unilateral stimulation of the STN may have minimal effects on risk-avoidant behaviors in PD. However, additional research is required to fully understand the mechanisms responsible for changes in anxiety during STN DBS for PD.
Details
- Language :
- English
- ISSN :
- 02196352
- Volume :
- 23
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Integrative Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.55e11ddd812346e9ab273436d51baa71
- Document Type :
- article
- Full Text :
- https://doi.org/10.31083/j.jin2304084