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Molecularly Imprinted Polymeric Nanoparticles as Drug Delivery System for Tenofovir, an Acyclic Nucleoside Phosphonate Antiviral

Authors :
Thomas Mathieu
Patrick Favetta
Luigi A. Agrofoglio
Source :
Pharmaceutics, Vol 16, Iss 7, p 965 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

A molecularly imprinted polymer of Tenofovir (1), an FDA-approved acyclic nucleoside phosphonate with antiviral activity, was synthesized using a non-covalent approach. A pre-polymerization complex was formed between (1) and DMAEMA and in-house synthetic N1-[(2-methacryloyloxy)ethyl] thymine, with EGDMA as a cross-linker in an MeCN/H2O (9:1, 1:1) mixture as a porogen, giving an imprinting factor (IF) of 5.5 at 2.10−5 mol/L. Binding parameters were determined by the Freundlich–Langmuir model, Qmax and Ka, and well as the particle morphology for MIP and NIP. Finally, the release profiles, for MIP and NIP, were obtained at 25 °C and 37 °C, which is body temperature, in a phosphate buffer saline, pH 7.4, mimicking the blood pH value, to determine the potential sustained release of our polymeric materials.

Details

Language :
English
ISSN :
19994923
Volume :
16
Issue :
7
Database :
Directory of Open Access Journals
Journal :
Pharmaceutics
Publication Type :
Academic Journal
Accession number :
edsdoj.55a4d2c9f949422ea8bff364132e6386
Document Type :
article
Full Text :
https://doi.org/10.3390/pharmaceutics16070965