Expression and clinical significance of Claudin-1 and Claudin-3 in the serum of patients with psoriasis vulgaris

Objective To investigate the expression and clinical significance of serum Claudin-1 and Claudin-3 levels in patients with psoriasis vulgaris (PV). Methods A total of 122 patients with PV were enrolled as the PV group (including 36 cases in the mild group, 54 cases in the moderate group, 32 cases in the severe group), and 60 healthy controls were enrolled from the physical examination center. The serum levels of hypersensitive C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), interleukin6 (IL-6), Claudin-1 and Claudin-3 were measured using enzyme linked immunosorbent assay (ELISA). Logistic regression was used to analyze the relationship between serum levels of Claudin-1 and Claudin-3 and PV severity, and the receiver operating characteristic (ROC) curve was used to analyze its diagnostic value. Results The levels of hs-CRP, TNF-α and IL-6 in PV group were significantly higher than that in the controls (P