Back to Search Start Over

From Diabetes Care to Heart Failure Management: A Potential Therapeutic Approach Combining SGLT2 Inhibitors and Plant Extracts

Authors :
Micaela Gliozzi
Roberta Macrì
Anna Rita Coppoletta
Vincenzo Musolino
Cristina Carresi
Miriam Scicchitano
Francesca Bosco
Lorenza Guarnieri
Antonio Cardamone
Stefano Ruga
Federica Scarano
Saverio Nucera
Rocco Mollace
Irene Bava
Rosamaria Caminiti
Maria Serra
Jessica Maiuolo
Ernesto Palma
Vincenzo Mollace
Source :
Nutrients, Vol 14, Iss 18, p 3737 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Diabetes is a complex chronic disease, and among the affected patients, cardiovascular disease (CVD)is the most common cause of death. Consequently, the evidence for the cardiovascular benefit of glycaemic control may reduce long-term CVD rates. Over the years, multiple pharmacological approaches aimed at controlling blood glucose levels were unable to significantly reduce diabetes-related cardiovascular events. In this view, a therapeutic strategy combining SGLT2 inhibitors and plant extracts might represent a promising solution. Indeed, countering the main cardiometabolic risk factor using plant extracts could potentiate the cardioprotective action of SGLT2 inhibitors. This review highlights the main molecular mechanisms underlying these beneficial effects that could contribute to the better management of diabetic patients.

Details

Language :
English
ISSN :
20726643
Volume :
14
Issue :
18
Database :
Directory of Open Access Journals
Journal :
Nutrients
Publication Type :
Academic Journal
Accession number :
edsdoj.558141873a16417082468debe70c0ec6
Document Type :
article
Full Text :
https://doi.org/10.3390/nu14183737