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Stretching muscle cells induces transcriptional and splicing transitions and changes in SR proteins

Authors :
Emma R. Hinkle
R. Eric Blue
Yi-Hsuan Tsai
Matthew Combs
Jacquelyn Davi
Alisha R. Coffey
Aladin M. Boriek
Joan M. Taylor
Joel S. Parker
Jimena Giudice
Source :
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Mechanical stretching of skeletal muscle cells induces extensive transcriptional and posttranscriptional changes in genes encoding proteins involved in transcription and muscle cell differentiation. SR proteins also exhibit altered transcription and phosphorylation in response to stretch.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
5
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.55751ccbbfbc4c3fb89674d0564d77b2
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-022-03915-7