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Advanced Echocardiographic Analysis in Medium-Term Follow-Up of Children with Previous Multisystem Inflammatory Syndrome

Authors :
Massimo Garbin
Irene Raso
Alessandra Piersanti
Laura Gianolio
Annalisa De Silvestri
Valeria Calcaterra
Carla G. Corti
Luisa F. Nespoli
Sara Santacesaria
Giulia Fini
Dario Dilillo
Gianvincenzo Zuccotti
Savina Mannarino
Source :
Children, Vol 9, Iss 6, p 917 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Multisystem inflammatory syndrome in children (MIS-C) is a severe hyperinflammatory disease related to SARS-CoV2 infection, with frequent cardiovascular involvement in the acute setting. The aim of the study was to evaluate the cardiac function at 6 months. Thirty-two patients diagnosed with MIS-C were enrolled and underwent advanced echocardiogram at discharge and at 6 months. According to the left ventricular ejection fraction (LVEF) at admission, the patients were divided into group A (LVEF < 45%) and group B (LVEF ≥ 45%) and the follow-up results were compared. At discharge, all patients had normal LV and RV systolic function (LVEF 61 ± 4.4%, LV global longitudinal strain −22.1%, TAPSE 20.1mm, s’ wave 0.13m/s, RV free wall longitudinal strain −27.8%) with normal LV diastolic function (E/A 1.5, E/e’ 5.7, and left atrial strain 46.5%) and no significant differences at 6 months. Compared to group B, the group A patients showed a reduced, even if normal, LV global longitudinal strain at discharge (−21.1% vs. −22.6%, p-value 0.02), but the difference was no longer significant at the follow-up. Patients with MIS-C can present with depressed cardiac function, but if treated, the cardiac function recovered without late onset of cardiac disease. This favorable result was independent of the severity of acute LV dysfunction.

Details

Language :
English
ISSN :
22279067
Volume :
9
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Children
Publication Type :
Academic Journal
Accession number :
edsdoj.5571cf82418043bdbcc15d7a2760c525
Document Type :
article
Full Text :
https://doi.org/10.3390/children9060917