Association of rs6265 and rs2030324 polymorphisms in brain-derived neurotrophic factor gene with Alzheimer's disease: a meta-analysis.

Authors :: Yan Lin
Shuo Cheng
Zhutian Xie
Dongfeng Zhang
Source :: PLoS ONE, Vol 9, Iss 4, p e94961 (2014)
Publication Year :: 2014
Publisher :: Public Library of Science (PLoS), 2014.
Abstract: BACKGROUND: The association between polymorphisms rs6265 and rs2030324 in brain-derived neurotrophic factor (BDNF) and Alzheimer's disease (AD) has been widely reported, but the results remain controversial. METHODS: A comprehensive search of Pubmed, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang Med Online and China Biology Medical literature database (CBM) was performed. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using fixed or random-effects models. We excluded the studies with OR>3.0 or OR

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