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Altered mannose metabolism in chronic stress and depression is rapidly reversed by vitamin B12

Authors :
Patricia Franzka
Gustavo Turecki
Susana Cubillos
Takfarinas Kentache
Johann Steiner
Martin Walter
Christian A. Hübner
Olivia Engmann
Source :
Frontiers in Nutrition, Vol 9 (2022)
Publication Year :
2022
Publisher :
Frontiers Media S.A., 2022.

Abstract

GDP-Mannose Pyrophosphorylase B (GMPPB) is a key enzyme for glycosylation. Previous studies suggested a dysregulation of GMPBB and mannose in depression. Evidence, however, was sporadic and interventions to reverse these changes are unknown. Here, we show that GMPPB protein, but not RNA abundance is increased in the postmortem prefrontal cortex (PFC) of depressed patients and the chronic variable stress (CVS) mouse-model. This is accompanied by higher plasma mannose levels. Importantly, a single dose of intraperitoneally administered vitamin B12, which has previously been shown to rapidly reverse behavioral symptoms and molecular signatures of chronic stress in mice, normalized GMPPB plasma mannose levels and elevated GDP-mannose abundance. In summary, these data underline metabolic dysregulation in chronic stress and depression and provide further support for rapid effects of vitamin B12 on chronic stress.

Details

Language :
English
ISSN :
2296861X
Volume :
9
Database :
Directory of Open Access Journals
Journal :
Frontiers in Nutrition
Publication Type :
Academic Journal
Accession number :
edsdoj.552c39645714855956a5d5984d2a5b9
Document Type :
article
Full Text :
https://doi.org/10.3389/fnut.2022.981511