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Activation of Oncogenic Pathways in Idiopathic Pulmonary Fibrosis

Authors :
Giulia M. Stella
Simona Inghilleri
Ymera Pignochino
Michele Zorzetto
Tiberio Oggionni
Patrizia Morbini
Maurizio Luisetti
Source :
Translational Oncology, Vol 7, Iss 5, Pp 650-655 (2014)
Publication Year :
2014
Publisher :
Elsevier, 2014.

Abstract

Idiopathic pulmonary fibrosis (IPF) is defined as a specific form of chronic, progressive fibrosing interstitial pneumonia of unknown cause. The most recent hypotheses on IPF pathogenesis suggest a central role of epithelial cell damage, followed by a dysregulated molecular cross talk between epithelial cells and fibroblasts. Thus, IPF progression has often been assimilated to that of cancer, and several signaling patterns appear to be disrupted in both diseases. Here, we analyze the expression in an IPF series of a panel of molecules, which are known to play a role in tumorigenic process. Our findings, although preliminary, reveal that IPF landscape is enriched in neoplastic potential expressed in a context of complex genomic polyclonality and cellular heterogeneity. These results provide a rationale for further investigations aimed to exploit—in a similar fashion to cancer—targeted therapies for a “precision medicine” approach to IPF.

Details

Language :
English
ISSN :
19365233 and 19447124
Volume :
7
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Translational Oncology
Publication Type :
Academic Journal
Accession number :
edsdoj.54f1cd3d07a747c4b0eb049668b9c7dc
Document Type :
article
Full Text :
https://doi.org/10.1016/j.tranon.2014.05.002