An inhalable nanoparticulate STING agonist synergizes with radiotherapy to confer long-term control of lung metastases

Successful anticancer immunotherapy should induce robust systemic immunity against metastases. Here, the authors engineer an inhalable nano-STING agonist, which synergizes with fractionated radiation to control lung metastases and confers long-term systemic antitumor immunity in mice.