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Etomidate affects the anti-oxidant pathway to protect retinal ganglion cells after optic nerve transection

Authors :
Xuan Zhao
Fang Kuang
Yi-Yan You
Ming-Mei Wu
Si-Wei You
Source :
Neural Regeneration Research, Vol 14, Iss 11, Pp 2020-2024 (2019)
Publication Year :
2019
Publisher :
Wolters Kluwer Medknow Publications, 2019.

Abstract

Our previous studies revealed that etomidate, a non-barbiturate intravenous anesthetic agent, has protective effects on retinal ganglion cells within 7 days after optic nerve transection. Whether this process is related to anti-oxidative stress is not clear. To reveal its mechanism, we established the optic nerve transection injury model by transecting 1 mm behind the left eyeball of adult male Sprague-Dawley rats. The rats received an intraperitoneal injection of etomidate (4 mg/kg) once per day for 7 days. The results showed that etomidate significantly enhanced the number of retinal ganglion cells retrogradely labeled with Fluorogold at 7 days after optic nerve transection. Etomidate also significantly reduced the levels of nitric oxide and malonaldehyde in the retina and increased the level of glutathione at 12 hours after optic nerve transection. Thus, etomidate can protect retinal ganglion cells after optic nerve transection in adult rats by activating an anti-oxidative stress response. The study was approved by the Animal Ethics Committee at Air Force Medical University, China (approval No. 20180305) on March 5, 2018.

Details

Language :
English
ISSN :
16735374
Volume :
14
Issue :
11
Database :
Directory of Open Access Journals
Journal :
Neural Regeneration Research
Publication Type :
Academic Journal
Accession number :
edsdoj.54dec6c08f64fb183783766bf4de0ca
Document Type :
article
Full Text :
https://doi.org/10.4103/1673-5374.259627