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Innate immune responses and antioxidant/oxidant imbalance are major determinants of human Chagas disease.
- Source :
- PLoS Neglected Tropical Diseases, Vol 7, Iss 8, p e2364 (2013)
- Publication Year :
- 2013
- Publisher :
- Public Library of Science (PLoS), 2013.
-
Abstract
- We investigated the pathological and diagnostic role of selected markers of inflammation, oxidant/antioxidant status, and cellular injury in human Chagas disease.Seropositive/chagasic subjects characterized as clinically-symptomatic or clinically-asymptomatic (n = 116), seronegative/cardiac subjects (n = 102), and seronegative/healthy subjects (n = 45) were analyzed for peripheral blood biomarkers.Seropositive/chagasic subjects exhibited an increase in sera or plasma levels of myeloperoxidase (MPO, 2.8-fold), advanced oxidation protein products (AOPP, 56%), nitrite (5.7-fold), lipid peroxides (LPO, 12-17-fold) and malondialdehyde (MDA, 4-6-fold); and a decline in superoxide dismutase (SOD, 52%) and glutathione (GSH, 75%) contents. Correlation analysis identified a significant (p0.95). The MPO (r = 0.664) and LPO (r = 0.841) levels were also correlated with clinical disease state in chagasic subjects (p
- Subjects :
- Arctic medicine. Tropical medicine
RC955-962
Public aspects of medicine
RA1-1270
Subjects
Details
- Language :
- English
- ISSN :
- 19352727 and 19352735
- Volume :
- 7
- Issue :
- 8
- Database :
- Directory of Open Access Journals
- Journal :
- PLoS Neglected Tropical Diseases
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.54d146507743a88fca0c66d9832747
- Document Type :
- article
- Full Text :
- https://doi.org/10.1371/journal.pntd.0002364