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Deciphering the spectrum of cutaneous lymphomas expressing TFH markers

Authors :
Marie Donzel
Alexis Trecourt
Brigitte Balme
Olivier Harou
Claire Mauduit
Emmanuel Bachy
Hervé Guesquières
Juliette Fontaine
Nicolas Ortonne
Marie Perier-Muzet
Stéphane Dalle
Alexandra Traverse-Glehen
Source :
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

Abstract T-follicular helper (TFH) markers are expressed in the microenvironnement of marginal zone B-cell lymphoma (MZL), and in lymphomas arising from TFH-cells, sometimes making the differential diagnosis difficult. In the skin, the “TFH-spectrum” is poorly defined, going from primary cutaneous lymphoproliferative disorder with small/medium CD4+ T-cells (SMLPD) to cutaneous localizations of systemic angioimmunoblastic T-cell lymphoma (cAITL), and may pass through intermediate forms (primary cutaneous T-follicular helper derived lymphoma, not otherwise specified (PCTFHL,NOS)). We retrospectively analyzed 20 MZL, 13 SMLPD, 5 PCTFHL, and 11 cAITL clinically, histologically, and molecularly, to define tools to differentiate them. Characteristics that might favor the diagnosis of MZL over SMLPD are: multiple skin nodules (p

Subjects

Subjects :
Medicine
Science

Details

Language :
English
ISSN :
20452322
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Scientific Reports
Publication Type :
Academic Journal
Accession number :
edsdoj.54a593c3fb5143aab69500652fae8e26
Document Type :
article
Full Text :
https://doi.org/10.1038/s41598-023-33031-3