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Depression-related anterior cingulate prefrontal resting state connectivity normalizes following cognitive behavioral therapy
- Source :
- European Psychiatry, Vol 63 (2020)
- Publication Year :
- 2020
- Publisher :
- Cambridge University Press, 2020.
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Abstract
- AbstractBackground.Aberrant activity of the subcallosal cingulate (SCC) is a common theme across pharmacologic treatment efficacy prediction studies. The functioning of the SCC in psychotherapeutic interventions is relatively understudied, as are functional differences among SCC subdivisions. We conducted functional connectivity analyses (rsFC) on resting-state functional magnetic resonance imaging (fMRI) data, collected before and after a course of cognitive behavioral therapy (CBT) in patients with major depressive disorder (MDD), using seeds from three SCC subdivisions.Methods.Resting-state data were collected from unmedicated patients with current MDD (Hamilton Depression Rating Scale-17 > 16) before and after 14-sessions of CBT monotherapy. Treatment outcome was assessed using the Beck Depression Inventory (BDI). Rostral anterior cingulate (rACC), anterior subcallosal cingulate (aSCC), and Brodmann’s area 25 (BA25) masks were used as seeds in connectivity analyses that assessed baseline rsFC and symptom severity, changes in connectivity related to symptom improvement after CBT, and prediction of treatment outcomes using whole-brain baseline connectivity.Results.Pretreatment BDI negatively correlated with pretreatment rACC ~ dorsolateral prefrontal cortex and aSCC ~ lateral prefrontal cortex rsFC. In a region-of-interest longitudinal analysis, rsFC between these regions increased post-treatment (p
Details
- Language :
- English
- ISSN :
- 09249338 and 17783585
- Volume :
- 63
- Database :
- Directory of Open Access Journals
- Journal :
- European Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.546a352fade418e883c0df6eea62e40
- Document Type :
- article
- Full Text :
- https://doi.org/10.1192/j.eurpsy.2020.34