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The use of the soluble receptor for advanced glycation-end products (sRAGE) as a potential biomarker of disease risk and adverse outcomes

Authors :
Jorge D. Erusalimsky
Source :
Redox Biology, Vol 42, Iss , Pp 101958- (2021)
Publication Year :
2021
Publisher :
Elsevier, 2021.

Abstract

The soluble receptor for advanced glycation end-products (sRAGE) has been classically considered a sink for pro-inflammatory RAGE ligands and as such has been associated with protection from inflammatory stress and disease. An alternative, though not mutually exclusive view is that high levels of sRAGE in circulation reflect the overstimulation of cell surface RAGE which if persistent, lead to the amplification of pro-inflammatory processes and the exacerbation of pathological states. With these two scenarios in mind this review focuses on the potential role of sRAGE as a prospective biomarker of disease risk and adverse outcomes.

Details

Language :
English
ISSN :
22132317
Volume :
42
Issue :
101958-
Database :
Directory of Open Access Journals
Journal :
Redox Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.54528792264e409b2f902fe5a9fe76
Document Type :
article
Full Text :
https://doi.org/10.1016/j.redox.2021.101958