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Prevalence, incidence, and mortality of nontuberculous mycobacterial infection in Korea: a nationwide population-based study

Authors :
Seon Cheol Park
Min Jin Kang
Chang Hoon Han
Sun Min Lee
Cheong Ju Kim
Jung Mo Lee
Young Ae Kang
Source :
BMC Pulmonary Medicine, Vol 19, Iss 1, Pp 1-9 (2019)
Publication Year :
2019
Publisher :
BMC, 2019.

Abstract

Abstract Background Epidemiologic characteristics of nontuberculous mycobacterial (NTM) disease remain largely unknown. The objective of this study was to evaluate incidence, prevalence, and mortality of NTM infection in a large nationwide population-based cohort in Korea. Methods Data of the National Health Insurance Service database, an extensive health-related database including most Korean residents, were used. Adults with a primary diagnosis of NTM as determined by International Classification of Disease-Tenth Revision coding (A31) were identified between 2003 and 2016. Incidence, prevalence, and mortality of NTM infection were analyzed. Results A total of 46,194 individuals had a primary diagnosis of NTM infection. Their mean age was 55.8 years. Of these subjects, 61.1% were females. Annual age-adjusted incidence and prevalence of NTM infection tended to increase rapidly from 2003 to 2016. Age-adjusted incidence and prevalence was 17.9 and 33.3 per 100,000 population in 2016. The incidence and prevalence were higher in females and the elderly. The 5-year mortality rate in the population with NTM infection was 17.8%. The standardized mortality ratio of patients with NTM infection to the general population was 2.16 (95% confidence interval: 2.10 to 2.22). Conclusions This large population-based study showed that the incidence and prevalence of NTM infection in Korea increased rapidly from 2003 to 2016. They were higher in women and the elderly. The mortality rate in the population with NTM infection was higher than that in the general population.

Details

Language :
English
ISSN :
14712466
Volume :
19
Issue :
1
Database :
Directory of Open Access Journals
Journal :
BMC Pulmonary Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.5405a61dcc364294b115de5af2366886
Document Type :
article
Full Text :
https://doi.org/10.1186/s12890-019-0901-z