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Postsynaptic RIM1 modulates synaptic function by facilitating membrane delivery of recycling NMDARs in hippocampal neurons

Authors :
Jiejie Wang
Xinyou Lv
Yu Wu
Tao Xu
Mingfei Jiao
Risheng Yang
Xia Li
Ming Chen
Yinggang Yan
Changwan Chen
Weifan Dong
Wei Yang
Min Zhuo
Tao Chen
Jianhong Luo
Shuang Qiu
Source :
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Publication Year :
2018
Publisher :
Nature Portfolio, 2018.

Abstract

Rab3-interacting molecules (RIMs) are a key component of the presynaptic active zone that regulate neurotransmitter release. Here, the authors show that RIM1 also has postsynaptic function to organize NMDA receptors and synaptic response.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
9
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.53f95c46d3ad4568a76275b5b8ee1546
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-04672-0