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Exploration of sensory and spinal neurons expressing gastrin-releasing peptide in itch and pain related behaviors

Authors :
Devin M. Barry
Xue-Ting Liu
Benlong Liu
Xian-Yu Liu
Fang Gao
Xiansi Zeng
Juan Liu
Qianyi Yang
Steven Wilhelm
Jun Yin
Ailin Tao
Zhou-Feng Chen
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

The role of gastrin related peptide (GRP+) neurons in itch is debated. Here, the authors generate a conditional knock-in mouse to label and manipulate GRP expressing DRG neurons and investigate their role in itch and nociception.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.53f793802fe24f6f9367fe8f40d917ea
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-15230-y