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Coumarinolignoid and Indole Alkaloids from the Roots of the Hybrid Plant Citrus × paradisi Macfad (Rutaceae)

Authors :
Fanny-Aimée Essombe Malolo
Ariane Dolly Kenmogne Kouam
Judith Caroline Ngo Nyobe
Lidwine Ngah
Marcel Frese
Jean Claude Ndom
Moses K. Langat
Bruno Ndjakou Lenta
Dulcie A. Mulholland
Norbert Sewald
Jean Duplex Wansi
Source :
Molecules, Vol 28, Iss 3, p 1078 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

A phytochemical investigation of the roots of Citrus × paradisi Macfad. (Rutaceae) led to the isolation of two new compounds, namely 1-formyl-5-hydroxy-N-methylindolin-1-ium (1) and decyloxycleomiscosin D (2), along with ten known compounds: 1,1-dimethylpyrrolidin-1-ium-2-carboxylate (3), furan-2,3-diol (4), 5-methoxyseselin (5), umbelliferone (6), scopoletin (7), citracridone I (8), citracridone II (9), citracridone III (10), limonin (11) and lupeol (12). The structures were determined through the comprehensive spectroscopic analysis of 1D and 2D NMR and EI- and ESI-MS, as well as a comparison with the published data. Notably, compounds 3 and 4 from the genus Citrus are reported here for the first time. In addition, the MeOH extract of the roots and compounds 1–7 were screened against the human adenocarcinoma alveolar basal epithelial cell line A549 and the Caucasian prostate adenocarcinoma cell line PC3 using the MTT assay. While the extract showed significant activity, with IC50 values of 35.2 and 38.1 µg/mL, respectively, compounds 1–7 showed weak activity, with IC50 values of 99.2 to 250.2 µM and 99.5 to 192.7 µM, respectively.

Details

Language :
English
ISSN :
14203049
Volume :
28
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
edsdoj.53ee43f2d5094e148e94f574ea3fc3f9
Document Type :
article
Full Text :
https://doi.org/10.3390/molecules28031078