Back to Search
Start Over
Antimalarial activity of primaquine operates via a two-step biochemical relay
- Source :
- Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
- Publication Year :
- 2019
- Publisher :
- Nature Portfolio, 2019.
-
Abstract
- Primaquine (PQ) is a widely used anti-malaria drug, but its mechanism of action is unclear. Here, Camarda et al. show that PQ’s activity against liver and sexual Plasmodium stages depends on generation of hydroxylated-PQ metabolites (OH-PQm), which, undergoing further reactions, results in production of H2O2.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 10
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.53df786506df4fffaf54431621d57eba
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-019-11239-0