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Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor

Authors :
Dirk Roymans
Sarhad S Alnajjar
Michael B Battles
Panchan Sitthicharoenchai
Polina Furmanova-Hollenstein
Peter Rigaux
Joke Van den Berg
Leen Kwanten
Marcia Van Ginderen
Nick Verheyen
Luc Vranckx
Steffen Jaensch
Eric Arnoult
Richard Voorzaat
Jack M. Gallup
Alejandro Larios-Mora
Marjolein Crabbe
Dymphy Huntjens
Pierre Raboisson
Johannes P. Langedijk
Mark R. Ackermann
Jason S McLellan
Sandrine Vendeville
Anil Koul
Source :
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Publication Year :
2017
Publisher :
Nature Portfolio, 2017.

Abstract

Respiratory syncytial virus causes lung infections in children, immunocompromised adults, and in the elderly. Here the authors show that a chemical inhibitor to a viral fusion protein is effective in reducing viral titre and ameliorating infection in rodents and neonatal lambs.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.53af0caadf64c108081ce0c70f541ee
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-017-00170-x