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Vascular Endothelial Growth Factor (VEGF) and Its Role in the Cardiovascular System

Authors :
Kamila Florek
Dominik Mendyka
Krzysztof Gomułka
Source :
Biomedicines, Vol 12, Iss 5, p 1055 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Cardiovascular diseases remain the leading cause of death worldwide, with ischemic heart disease (IHD) as the most common. Ischemia-induced angiogenesis is a process in which vascular endothelial growth factor (VEGF) plays a crucial role. To conduct research in the field of VEGF’s association in cardiovascular diseases, it is vital to understand its role in the physiological and pathological processes in the heart. VEGF-based therapies have demonstrated a promising role in preclinical studies. However, their potential in human therapies is currently under discussion. Furthermore, VEGF is considered a potential biomarker for collateral circulation assessment and heart failure (HF) mortality. Additionally, as VEGF is involved in angiogenesis, there is a need to elucidate the impact of VEGF-targeted therapies in terms of cardiovascular side effects.

Details

Language :
English
ISSN :
12051055 and 22279059
Volume :
12
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Biomedicines
Publication Type :
Academic Journal
Accession number :
edsdoj.53372e924d7341c49b1c2f0c0b4a16f8
Document Type :
article
Full Text :
https://doi.org/10.3390/biomedicines12051055