Back to Search
Start Over
A chromatin-based signalling mechanism directs the switch from mutagenic to error-free repair of DNA double strand breaks
- Source :
- Molecular & Cellular Oncology, Vol 6, Iss 4 (2019)
- Publication Year :
- 2019
- Publisher :
- Taylor & Francis Group, 2019.
-
Abstract
- Mutations caused by DNA damage are a main driver of cancer. We discovered that recognition of newly synthesised histone H4 directs breast cancer type 1 susceptibility protein (BRCA1) to post-replicative chromatin. The switch from mutagenic to error-free DNA double strand break repair by homologous recombination is therefore controlled by chromatin.
Details
- Language :
- English
- ISSN :
- 23723556
- Volume :
- 6
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Molecular & Cellular Oncology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.532cf4e4b4829a6d83ab7e764723e
- Document Type :
- article
- Full Text :
- https://doi.org/10.1080/23723556.2019.1605820