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Amomum villosum Lour. Fruit extract mitigates hyperlipidemia through SREBP-2/LDLR/HMGCR signaling in high-cholesterol diet-fed mice
- Source :
- Journal of King Saud University: Science, Vol 34, Iss 7, Pp 102230- (2022)
- Publication Year :
- 2022
- Publisher :
- Elsevier, 2022.
-
Abstract
- Amomum villosum Lour. (Zingiberaceae) is an herbal medicine used in Asian countries for various ailments. In the current experiment, the effect of AV water extract (AVE) on cholesterol-lowering capabilities along with its essential bio-molecular mechanisms have been examined. The efficiency of AVE against high-cholesterol diet (HCD)-generated hyperlipidemia was investigated using C57BL/6 mice. Mice have been divided to six categories: control group (normal diet), high-cholesterol diet (HCD), and HCD treated with AVE at 100, 200, and 500 mg/kg, or simvastatin 40 mg/kg for four weeks. AVE treated animal groups (100, 200, 500 mg/kg) had markedly lessened body mass increase (p
- Subjects :
- Amomum villosum
LDL receptor
SREBP-2
HMGCR
LDL cholesterol
Science (General)
Q1-390
Subjects
Details
- Language :
- English
- ISSN :
- 10183647
- Volume :
- 34
- Issue :
- 7
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of King Saud University: Science
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.52f7d259bb4491eb75d2f1a8f07111f
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.jksus.2022.102230