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Plasmodium vivax blood stage invasion pathways: Contribution of omics technologies in deciphering molecular and cellular mechanisms

Authors :
Bouyssou, Isabelle
Martínez, Francisco José
Campagne, Pascal
Ma, Laurence
Doderer-Lang, Cécile
Chitnis, Chetan E.
Ménard, Didier
Source :
Comptes Rendus Biologies, Vol 345, Iss 2, Pp 91-133 (2022)
Publication Year :
2022
Publisher :
Académie des sciences, 2022.

Abstract

Vivax malaria is an infectious disease caused by Plasmodium vivax, a parasitic protozoan transmitted by female Anopheline mosquitoes. Historically, vivax malaria has often been regarded as a benign self-limiting infection due to the observation of low parasitemia in Duffy-positive patients in endemic transmission areas and the virtual absence of infections in Duffy-negative individuals in Sub Saharan Africa. However, the latest estimates show that the burden of the disease is not decreasing in many countries and cases of vivax infections in Duffy-negative individuals are increasingly reported throughout Africa. This raised questions about the accuracy of diagnostics and the evolution of interactions between humans and parasites. For a long time, our knowledge on P. vivax biology has been hampered due to the limited access to biological material and the lack of robust in vitro culture methods. Consequently, little is currently known about P. vivax blood stage invasion mechanisms. The introduction of omics technologies with novel and accessible techniques such as third generation sequencing and RNA sequencing at single cell level, two-dimensional electrophoresis, liquid chromatography, and mass spectrometry, has progressively improved our understanding of P. vivax genetics, transcripts, and proteins. This review aims to provide broad insights into P. vivax invasion mechanisms generated by genomics, transcriptomics, and proteomics and to illustrate the importance of integrated multi-omics studies.

Details

Language :
English, French
ISSN :
17683238
Volume :
345
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Comptes Rendus Biologies
Publication Type :
Academic Journal
Accession number :
edsdoj.526a694d518e427caeee9b135b014fa7
Document Type :
article
Full Text :
https://doi.org/10.5802/crbiol.95