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Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS

Authors :
Xue Wu
Cristina M. Niculite
Mihai Bogdan Preda
Annalisa Rossi
Toma Tebaldi
Elena Butoi
Mattie K. White
Oana M. Tudoran
Daniela N. Petrusca
Amber S. Jannasch
William P. Bone
Xingyue Zong
Fang Fang
Alexandrina Burlacu
Michelle T. Paulsen
Brad A. Hancock
George E. Sandusky
Sumegha Mitra
Melissa L. Fishel
Aaron Buechlein
Cristina Ivan
Spyros Oikonomopoulos
Myriam Gorospe
Amber Mosley
Milan Radovich
Utpal P. Davé
Jiannis Ragoussis
Kenneth P. Nephew
Bernard Mari
Alan McIntyre
Heiko Konig
Mats Ljungman
Diana L. Cousminer
Paolo Macchi
Mircea Ivan
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

Noncoding transcripts contribute to the adaptation of cellular processes to oxygen levels. Here the authors characterize a hypoxia responsive lncRNA lincNORS and show that it has a role in cellular sterol homeostasis.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.52284dde8b4044179316ad15dd802151
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-18411-x