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Low Doses of Tetracycline Trigger the Growth: A Case of Hormetic Response
- Source :
- Dose-Response, Vol 11 (2013)
- Publication Year :
- 2013
- Publisher :
- SAGE Publishing, 2013.
-
Abstract
- Hormesis is a biphasic dose-response relationship, occurring when low concentrations of toxic agents elicit apparent improvements. In this work, the ability of sub-inhibitory concentrations of Tetracycline to induce hormetic response in a model organism was investigated. To this aim a reference strain of Escherichia coli , MG1655, was exposed to six decreasing doses of Tetracycline (between 0.12 and 0.00375 μg/ml), much lower than the Minimal Inhibitory Concentration (4 μg/ml). An hormetic increase was observed at the intermediate concentrations (0.015–0.03 μg/ml) of the tested range. The Colony Forming Unit number, indeed, rose up to 141% and 121% as compared to the control. At the highest (0.12 μg/ml) and lowest (0.00375 μg/ml) concentrations a slight decrease in CFU number was found. Results demonstrated that, in Escherichia coli , low concentrations of Tetracycline bias the bacterial numerical increase through a hormetic response; the dose-response curve describing this numerical increase is an U-inverted curve. Furthermore, these data confirm that hormesis is common to many - if not all - living systems, including bacteria; they underline the relevance of a deepened knowledge of both the effects and the possible consequences of exposure to low doses of contaminants.
- Subjects :
- Therapeutics. Pharmacology
RM1-950
Subjects
Details
- Language :
- English
- ISSN :
- 15593258
- Volume :
- 11
- Database :
- Directory of Open Access Journals
- Journal :
- Dose-Response
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.51cc50a764e34fcbb347c188c8c88f82
- Document Type :
- article
- Full Text :
- https://doi.org/10.2203/dose-response.13-002.Migliore